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GLOSSARY

Medical Terms

Learn about common terms related to PAH, TYVASO DPI, and TYVASO.

Portrait of happy couple taking a walk outdoors Portrait of happy couple taking a walk outdoors
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6-minute walk test (6MWT)

A test that tracks how far you can walk in 6 minutes. The 6-minute walk test is done during most of your doctor visits. The distance you can walk (known as your 6-minute walk distance, or 6MWD) helps your doctor assess the impact of your treatment and determine whether your treatment plan needs to be adjusted to improve your walk distance.

Experts recommend a treatment goal* of about 1444 feet or more (440 meters) in the 6-minute walk test.

*Low-risk 6MWD threshold from the 2015 ESC/ERS Guidelines for the Diagnosis and Treatment of Pulmonary Hypertension.

C

Cartridge

Cartridges are what hold the medicine you take with TYVASO DPI. Cartridges come in different colors depending on how much medicine is inside.

D

DPI

Dry powder inhaler. The device used with TYVASO DPI.

E

Endothelin receptor antagonist (ERA)

Class of medication used in PAH. Available in oral form. Ambrisentan, bosentan, and macitentan are ERAs.

F

Functional class (FC)

A system of 4 classes created by the World Health Organization to assess the severity of symptoms in patients with PAH.

N

Nebulizer

A portable device usable with TYVASO. A nebulizer changes medication from a liquid to a mist, allowing you to inhale it directly into your lungs.

P

Phosphodiesterase type 5 (PDE-5) inhibitor

Class of medication used to treat PAH. Available in oral form. Tadalafil and sildenafil are PDE-5 inhibitors.

Prostacyclin

A natural substance in your body that helps the blood vessels in your lungs stay open so that your heart can pump blood through your lungs.

Prostacyclin mimetic

A synthetic form of prostacyclin, designed to mimic some of the effects of natural prostacyclin, that helps to keep the blood flowing through your lungs. TYVASO is an inhaled prostacyclin mimetic used to treat pulmonary arterial hypertension (PAH; WHO Group 1).

Pulmonary arterial hypertension (PAH)

A condition that is characterized by high blood pressure in the arteries of the lungs. It is a chronic and progressive rare disease that affects your heart’s ability to pump blood to your lungs.

R

Right heart catheterization

The only test that can confirm a PAH diagnosis; measures the pressure in your heart and the arteries in your lungs.

S

Specialty Pharmacy (SP) providers

Pharmacies that provide personalized care and are different from your local pharmacy.

T

TYVASO

TYVASO (treprostinil) is a prescription medicine used in adults to treat PAH, which is high blood pressure in the arteries of your lungs. TYVASO can improve the ability to exercise.

IMPORTANT SAFETY
INFORMATION

Before you take TYVASO or TYVASO DPI, tell your healthcare provider about all of your medical conditions, including if you:

  • Have low blood pressure
  • Have or have had bleeding problems
EXPAND

IMPORTANT SAFETY
INFORMATION

COLLAPSE

Before you take TYVASO or TYVASO DPI, tell your healthcare provider about all of your medical conditions, including if you:

  • Have low blood pressure
  • Have or have had bleeding problems
  • Have asthma or chronic obstructive pulmonary disease (COPD)
  • Are pregnant or plan to become pregnant. It is not known if either product will harm your unborn baby.
  • Are breastfeeding or plan to breastfeed. It is not known if either product passes into your breast milk. Talk to your healthcare provider about the best way to feed your baby during treatment.

Tell your healthcare provider about all of the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements. Either product and other medicines may affect each other.

Especially tell your healthcare provider if you take:

  • Medicines used to treat high blood pressure or heart disease
  • Medicines that decrease blood clotting (anticoagulants)
  • Water pills (diuretics)
  • Gemfibrozil (Lopid®) or rifampin (Rimactane®, Rifadin®, Rifamate®, Rifater®)

What are the possible side effects of TYVASO or TYVASO DPI?

Both products can cause serious side effects, including:

  • Low blood pressure (symptomatic hypotension). If you have low blood pressure, either product may lower your blood pressure more.
  • Bleeding problems. Either product may increase the risk of bleeding, especially in people who take blood thinners (anticoagulants).

The most common side effects of both products are cough, headache, throat irritation and pain, nausea, reddening of the face and neck (flushing), fainting or loss of consciousness, dizziness, diarrhea, and shortness of breath. Like other inhaled prostaglandins, you may have trouble breathing after taking TYVASO or TYVASO DPI because it may cause the muscles around your airway to tighten (bronchospasm). These are not all the possible side effects. Call your doctor for medical advice about side effects or if you have trouble breathing.

You may report side effects to the FDA at 

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www.fda.gov/MedWatch

or call 1-800-FDA-1088.

What are TYVASO and TYVASO DPI?

TYVASO (treprostinil) Inhalation Solution and TYVASO DPI (treprostinil) Inhalation Powder are prescription medicines used in adults to treat:

  • Pulmonary arterial hypertension (PAH; WHO Group 1), which is high blood pressure in the arteries of your lungs. TYVASO or TYVASO DPI can improve the ability to exercise. Your ability to exercise decreases 4 hours after taking TYVASO or TYVASO DPI. It is not known if TYVASO or TYVASO DPI is safe and effective in children under 18 years of age.
  • Pulmonary hypertension associated with interstitial lung disease (PH-ILD; WHO Group 3), which is high blood pressure in the lungs due to inflammation and sometimes scarring in the lungs. TYVASO or TYVASO DPI can improve the ability to exercise.

The risk information provided here is not comprehensive. To learn more about TYVASO or TYVASO DPI, talk with your healthcare provider. Please see Full Prescribing Information for TYVASO or TYVASO DPI, Instructions for Use manuals for TD-100 and TD-300 TYVASO® Inhalation System and TYVASO DPI™ Inhalation Powder, and additional information at www.TYVASO.com or call 1-877-UNITHER (1-877-864-8437).


TYVISIconMAY2022

ERS=European Respiratory Society; ESC=European Society of Cardiology; WHO=World Health Organization.

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