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TYVASO and TYVASO DPI are approved for the treatment of pulmonary hypertension associated with interstitial lung disease (PH-ILD; WHO Group 3) to improve the ability to exercise.

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Effects & Symptoms of PH-ILD

WHAT HAPPENS INSIDE YOUR BODY WHEN YOU HAVE PH-ILD

Both ILD and PH affect the lungs, but PH also weakens the heart.

The impact of ILD + PH in your body

ILD impact on lungs icon

ILD causes lung tissue to become stiff, making it harder to breathe and get oxygen into the blood.

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Healthy blood vessel in the lungs compared to narrowed vessel with pulmonary hypertension

PH causes the blood vessels in the lungs to become narrow, making it harder for blood to flow and causing pressure to increase.

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PH-ILD and heart damage icon

The heart has to work harder to push blood through the lungs, which weakens or damages the heart.

PH can affect your ability to do the things you want to do, like being active and spending time with loved ones.

That’s why it’s so important to identify PH early and get ahead of it.

Knowing more may help you do more for your health.

The overlapping symptoms with ILD can make PH hard to detect

Some of the symptoms of PH that overlap with ILD include:

  • Fatigue
  • Shortness of breath
  • Reduced ability to be active

Symptoms to point out to your doctor:

  • Symptoms that seem worse than they were before, such as you can’t walk as far as you used to without resting
  • If supplemental oxygen is needed for the first time or if more is needed than previously used

It’s important to ask your doctor about checking for PH at each appointment—especially if you’ve noticed your symptoms getting worse.

Take steps to catch PH early

Ask your doctor to check for signs of PH in the tests you’re already doing.
Your existing ILD tests can help flag signs of early-stage PH, but your doctor needs to look at them with PH in mind.

Be vigilant and work with your doctor to watch for PH.
Your test results may contain signs of PH, but they could be easily missed unless your doctor checks specifically for those signs. That’s why it’s crucial that you ask to be checked for PH.

Take an Active Role with Your Doctor

Sign up for the Raise The Questions program with Coach Phil to get the specific questions and information to help prepare you for conversations with your doctor.

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Learn how your doctor can check for PH-ILD.

Work With Your Doctor

ILD=interstitial lung disease; PH=pulmonary hypertension.

IMPORTANT SAFETY
INFORMATION

Before you take TYVASO or TYVASO DPI, tell your healthcare provider about all of your medical conditions, including if you:

  • Have low blood pressure
  • Have or have had bleeding problems
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IMPORTANT SAFETY
INFORMATION

COLLAPSE

Before you take TYVASO or TYVASO DPI, tell your healthcare provider about all of your medical conditions, including if you:

  • Have low blood pressure
  • Have or have had bleeding problems
  • Have asthma or chronic obstructive pulmonary disease (COPD)
  • Are pregnant or plan to become pregnant. It is not known if either product will harm your unborn baby.
  • Are breastfeeding or plan to breastfeed. It is not known if either product passes into your breast milk. Talk to your healthcare provider about the best way to feed your baby during treatment.

Tell your healthcare provider about all of the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements. Either product and other medicines may affect each other.

Especially tell your healthcare provider if you take:

  • Medicines used to treat high blood pressure or heart disease
  • Medicines that decrease blood clotting (anticoagulants)
  • Water pills (diuretics)
  • Gemfibrozil (Lopid®) or rifampin (Rimactane®, Rifadin®, Rifamate®, Rifater®)

What are the possible side effects of TYVASO or TYVASO DPI?

Both products can cause serious side effects, including:

  • Low blood pressure (symptomatic hypotension). If you have low blood pressure, either product may lower your blood pressure more.
  • Bleeding problems. Either product may increase the risk of bleeding, especially in people who take blood thinners (anticoagulants).

The most common side effects of both products are cough, headache, throat irritation and pain, nausea, reddening of the face and neck (flushing), fainting or loss of consciousness, dizziness, diarrhea, and shortness of breath. Like other inhaled prostaglandins, you may have trouble breathing after taking TYVASO or TYVASO DPI because it may cause the muscles around your airway to tighten (bronchospasm). These are not all the possible side effects. Call your doctor for medical advice about side effects or if you have trouble breathing.

You may report side effects to the FDA at 

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or call 1-800-FDA-1088.

What are TYVASO and TYVASO DPI?

TYVASO (treprostinil) Inhalation Solution and TYVASO DPI (treprostinil) Inhalation Powder are prescription medicines used in adults to treat:

  • Pulmonary arterial hypertension (PAH; WHO Group 1), which is high blood pressure in the arteries of your lungs. TYVASO or TYVASO DPI can improve the ability to exercise. Your ability to exercise decreases 4 hours after taking TYVASO or TYVASO DPI. It is not known if TYVASO or TYVASO DPI is safe and effective in children under 18 years of age.
  • Pulmonary hypertension associated with interstitial lung disease (PH-ILD; WHO Group 3), which is high blood pressure in the lungs due to inflammation and sometimes scarring in the lungs. TYVASO or TYVASO DPI can improve the ability to exercise.

The risk information provided here is not comprehensive. To learn more about TYVASO or TYVASO DPI, talk with your healthcare provider. Please see Full Prescribing Information for TYVASO or TYVASO DPI, Instructions for Use manuals for TD-100 and TD-300 TYVASO® Inhalation System and TYVASO DPI® Inhalation Powder, and additional information at www.TYVASO.com or call 1-844-UNITHER (1-844-864-8437).


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